What is the difference between mononeuritis multiplex and polyneuropathy

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TPP Trainee Portal. Member Portal. Online Resource Library. Peripheral nervous system manifestations in systemic autoimmune diseases. Maedica Buchar. Radiation-induced neuropathy in cancer survivors. Radiother Oncol. Peripheral nervous system manifestations of infectious diseases. Overview of Polyneuropathy. Last updated: December 1, Said G. Uremic neuropathy. Elsevier ; : p. Updated: January 1, Accessed: June 13, Cutaneous thermal thresholds in patients with painful burning feet.

J Neurol Neurosurg Psychiatry. Peripheral neuropathy — clinical and electrophysiological considerations. Neuroimaging Clin N Am. EMG findings of axonal polyneuropathy. Laboratory Diagnosis of Peripheral Neuropathy.

Updated: September 1, Wright DV. Non-narcotic options for pain relief with chronic neuropathic conditions. Journal for Nurse Practitioners.

Jefferies K. Treatment of neuropathic pain. Tendon reflexes are depressed or absent. Paresthesias, pain, and muscle tenderness may also occur. Multiple mononeuropathies mononeuropathy multiplex suggest a patchy multifocal disease process such as vasculopathy eg, diabetes, arteritis , an infiltrative process eg, leprosy, sarcoidosis , radiation damage, or an immunologic disorder eg, brachial plexopathy.

The cause of polyneuropathy or mononeuritis multiplex is suggested by the history, mode of onset, and predominant clinical manifestations. Laboratory workup includes a complete blood count, serum protein electrophoresis with reflex to immunofixation or immunotyping, determination of plasma urea and electrolytes, liver biochemical tests, thyroid function tests, vitamin B 12 level, tests for rheumatoid factor and antinuclear antibody, HBsAg determination, a serologic test for syphilis, fasting blood glucose level and hemoglobin A 1c , urinary heavy metal levels, cerebrospinal fluid examination, and chest radiography.

These tests should be ordered selectively, as guided by symptoms and signs. Measurement of nerve conduction velocity can confirm the peripheral nerve origin of symptoms and provides a means of following clinical changes, as well as indicate the likely disease process ie, axonal or demyelinating neuropathy. Cutaneous nerve biopsy may help establish a precise diagnosis eg, polyarteritis, amyloidosis. In about half of cases, no specific cause can be established; of these, slightly less than half are subsequently found to be familial.

Treatment is of the underlying cause, when feasible, and is discussed below under the individual disorders. Physical therapy helps prevent contractures, and splints can maintain a weak extremity in a position of useful function. Anesthetic extremities must be protected from injury.

To guard against burns, patients should check the temperature of water and hot surfaces with a portion of skin having normal sensation, measure water temperature with a thermometer, and use cold water for washing or lower the temperature setting of their hot-water heaters.

Shoes should be examined frequently during the day for grit or foreign objects in order to prevent pressure lesions. Patients with polyneuropathies or mononeuritis multiplex are subject to additional nerve injury at pressure points and should therefore avoid such behavior as leaning on elbows or sitting with crossed legs for lengthy periods.

Neuropathic, burning pain may respond to simple analgesics, such as aspirin or nonsteroidal anti-inflammatory agents, From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world.

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Common Health Topics. Peripheral Nerve and Related Disorders. Test your knowledge. Bell palsy is sudden weakness or paralysis of the muscles on one side of the face due to malfunction of the seventh cranial nerve. This nerve moves facial muscles, stimulates salivary and tear glands, detects tastes, and controls a muscle involved in hearing.

Which of the following is often the first symptom of Bell palsy? More Content. A disorder may affect the nerves all at once or affect them progressively, a few at a time.